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Betamethasone Valerate Cream, Ointment and Lotion contain betamethasone valerate USP, a synthetic adrenocorticosteroid for dermatologic use. Betamethasone, an analog of prednisolone, has a high degree of glucocorticoid activity and a slight degree of mineralocorticoid activity.
Each gram of the 0.1% Cream, Ointment and Lotion contains 1.2 mg betamethasone valerate (equivalent to 1 mg betamethasone).
Indications and usage:
Topical corticosteroids including betamethasone cream, ointment, lotion are indicated for the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses, and to relieve inflammation caused by skin disorders.
Patients with a history of hypersensitivity to any of the components of this medication.
Dosage forms and strengths:
Dosage and administration:
Apply a thin film of betamethasone valerate cream or ointment to the affected skin areas one to three times a day. Dosage once or twice a day is often effective.
Apply a few drops of betamethasone valerate lotion or scalp lotion to the affected area and massage lightly until it disappears. Apply twice daily, in the morning and at night. Dosage may be increased in stubborn cases. Following improvement, apply once daily. For the most effective and economical use, apply nozzle very close to affected area and gently squeeze bottle.
Topically applied corticosteroids can be absorbed in sufficient amounts to produce systemic effects.
Warnings and precautions:
Systemic absorption of topical corticosteroids has produced reversible hypothalamic-pituitary-adrenal (HPA) axis suppression, manifestations of Cushing's syndrome, hyperglycemia, and glucosuria in some patients.
Conditions which augment systemic absorption include the application of the more potent steroids, use over large surface areas, prolonged use, and the addition of occlusive dressings.
Side effects, adverse reactions:
The following local adverse reactions are reported infrequently with betamethasone and other topical corticosteroids, but may occur more frequently with the use of occlusive dressings. These reactions are listed in an approximate decreasing order of occurrence: burning, itching, irritation, dryness, folliculitis, hypertrichosis, acneiform eruptions, hypopigmentation, perioral dermatitis, allergic contact dermatitis, maceration of the skin, secondary infection, skin atrophy, striae and miliaria.
To report suspected adverse reactions of betamethasone pills and topical forms contact pharmaceutical company manufactured or distributed this drug or your local FDA.
Co-administered drugs that can inhibit CYP3A4 (e.g. ritonavir, itraconazole) have been shown to inhibit the metabolism of betamethasone and other corticosteroids leading to increased systemic exposure. The extent to which this interaction is clinically relevant depends on the dose and route of administration of the corticosteroids and the potency of the CYP3A4 inhibitor.
Usage in specific populations:
Corticosteroids are generally teratogenic in laboratory animals when administered systemically at relatively low dosage levels. The more potent corticosteroids have been shown to be teratogenic after dermal application in laboratory animals. There are no adequate and well-controlled studies in pregnant women on teratogenic effects from topically applied corticosteroids.
It is not known whether topical administration of betamethasone and other corticosteroids could result in sufficient systemic absorption to produce detectable quantities in breast milk. Systemically administered corticosteroids are secreted into breast milk in quantities not likely to have a deleterious effect on the infant. Nevertheless, caution should be exercised when topical corticosteroids are administered to a nursing woman.
Pediatric patients may demonstrate greater susceptibility to topical corticosteroid-induced HPA axis suppression and Cushing's syndrome than mature patients because of a larger skin surface area to body weight ratio.
Information for patients:
Patients using topical corticosteroids should receive the following information and instructions:
Where to buy betamethasone online:
To purchase Betamethasone tablets, cream, ointment, lotion, scalp lotion from reliable online pharmacies and drugstores at low prices please use resources described above on this webpage.
Here is a list of popular medications containing betamethasone as a main active pharmaceutical ingredient; their trade names, forms, doses, companies - manufacturers, distributors, suppliers, researchers and developers:
|Trade name of the drug
|Pharmaceutical forms and doses